STOP-like Protein 21 Is a Novel Member of the STOP Family, Revealing a Golgi Localization of STOP Proteins
نویسندگان
چکیده
منابع مشابه
STOP-like protein 21 is a novel member of the STOP family, revealing a Golgi localization of STOP proteins.
Neuronal microtubules are stabilized by two calmodulin-regulated microtubule-associated proteins, E-STOP and N-STOP, which when suppressed in mice induce severe synaptic and behavioral deficits. Here we show that mature neurons also contain a 21-kDa STOP-like protein, SL21, which shares calmodulin-binding and microtubule-stabilizing homology domains with STOP proteins. Accordingly, in different...
متن کاملStop-like Protein 21: a Novel Member of the Stop Family Revealing a Golgi Localization of Stop Proteins
Neuronal microtubules are stabilized by two calmodulin-regulated microtubule associated proteins, E-STOP and N-STOP, whose suppression in mice induces severe synaptic and behavioral deficits. Here we show that mature neurons also contain a 21 kD STOP-like protein, SL21, which shares calmodulin-binding and microtubulestabilizing homology domains with STOP proteins. Accordingly, in different bioc...
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15 صفحه اولSTOP gene Phactr4 is a tumor suppressor.
Cancer develops through genetic and epigenetic alterations that allow unrestrained proliferation and increased survival. Using a genetic RNAi screen, we previously identified hundreds of suppressors of tumorigenesis and/or proliferation (STOP) genes that restrain normal cell proliferation. Our STOP gene set was significantly enriched for known and putative tumor suppressor genes. Here, we repor...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2006
ISSN: 0021-9258
DOI: 10.1074/jbc.m603380200