Stochastic dynamics of electrical membrane with voltage-dependent ion channel fluctuations
نویسندگان
چکیده
منابع مشابه
Stochastic Dynamics of Electrical Membrane with Voltage-Dependent Ion Channel Fluctuations
A Brownian ratchet like stochastic theory for the electrochemical membrane system of Hodgkin-Huxley (HH) is developed. The system is characterized by a continuous variable Qm(t), representing mobile membrane charge density, and a discrete variable Kt representing ion channel conformational dynamics. A Nernst-Planck-Nyquist-Johnson type equilibrium is obtained when multiple conducting ions have ...
متن کاملVoltage-Dependent Gating in a “Voltage Sensor-Less” Ion Channel
The voltage sensitivity of voltage-gated cation channels is primarily attributed to conformational changes of a four transmembrane segment voltage-sensing domain, conserved across many levels of biological complexity. We have identified a remarkable point mutation that confers significant voltage dependence to Kir6.2, a ligand-gated channel that lacks any canonical voltage-sensing domain. Simil...
متن کاملProper Voltage-Dependent Ion Channel Function in Dysferlin-Deficient Cardiomyocytes.
BACKGROUND/AIMS Dysferlin plays a decisive role in calcium-dependent membrane repair in myocytes. Mutations in the encoding DYSF gene cause a number of myopathies, e.g. limb-girdle muscular dystrophy type 2B (LGMD2B). Besides skeletal muscle degenerative processes, dysferlin deficiency is also associated with cardiac complications. Thus, both LGMD2B patients and dysferlin-deficient mice develop...
متن کاملPosition-dependent stochastic diffusion model of ion channel gating.
A position-dependent stochastic diffusion model of gating in ion channels is developed by considering the spatial variation of the diffusion coefficient between the closed and open states. It is assumed that a sensor which regulates the opening of the ion channel experiences Brownian motion in a closed region Rc and a transition region Rm, where the dynamics is described by probability densitie...
متن کاملFunctional dynamics in the voltage-dependent anion channel.
The voltage-dependent anion channel (VDAC), located in the outer mitochondrial membrane, acts as a gatekeeper for the entry and exit of mitochondrial metabolites. Here we reveal functional dynamics of isoform one of VDAC (VDAC1) by a combination of solution NMR spectroscopy, Gaussian network model analysis, and molecular dynamics simulation. Micro- to millisecond dynamics are significantly incr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: EPL (Europhysics Letters)
سال: 2014
ISSN: 0295-5075,1286-4854
DOI: 10.1209/0295-5075/106/10002