منابع مشابه
Tight Junctions
Epithelial cells cover the body (e.g. skin), cavities (e.g. stomach, uterus, bladder) and ducts (e.g. renal tubules, intestine) of multicellular organisms, and thus constitute the frontier between the individual and the external milieu. In areas that withstand strong mechanical or chemical stress (e.g. skin, esophagus, cornea, vagina) epithelia are stratified, whereas in the rest of the body, t...
متن کاملTight junctions
part of my lab in that direction with work on human embryonic stem cells which, as we have come to learn, show aberrant epigenetic regulation. There is a lot to learn from this much needed human model. What do you enjoy most about science? The challenge, the discovery, and the people. In this profession, one meets some of the brightest (and most eccentric) minds on Earth. Although I dislike air...
متن کاملTight junctions.
Tight junctions are the most apical intercellular junctions of epithelial and endothelial cells and create a regulatable semipermeable diffusion barrier between individual cells. On a cellular level, they form an intramembrane diffusion fence that restricts the intermixing of apical and basolateral membrane components. In addition to these well defined functions, more recent evidence suggests t...
متن کاملTight junctions loosen up
Tight junctions loosen up T ight junctions are more flexible than researchers realized, as Shen et al. show. The team discovered that proteins are constantly entering and leaving these connections between epithelial cells. The continual remodeling might allow organisms to adjust the perme-ability of cell layers. In locations such as the skin and the lining of the intestines , epithelial cells s...
متن کاملSnapShot: Epithelial Tight Junctions
Tight junctions form a morphological and functional border between the apical and basolateral cell surface domains that serves as a paracellular diffusion barrier, enabling epithelial cells to separate compartments of different composition. Tight junctions also contribute to the generation and maintenance of cell polarity and regulate signaling mechanisms that guide cell behavior, shape, and ge...
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ژورنال
عنوان ژورنال: Cellular and Molecular Gastroenterology and Hepatology
سال: 2018
ISSN: 2352-345X
DOI: 10.1016/j.jcmgh.2017.12.007