STIMULATION OF THE PERIPHERAL CHEMORECEPTORS WITH SODIUM BICARBONATE

Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion.

Melatonin is released from intestinal enterochromaffin cells and from the pineal gland, but its role in gastrointestinal function is largely unknown. Our aim was to study the involvement of intestinal and central nervous melatonin in the neurohumoral control of the duodenal mucosa-protective bicarbonate secretion. Working in anesthetized rats, we cannulated a 12-mm segment of duodenum with an i...

Sodium bicarbonate

Major uses Sodium bicarbonate is a main constituent of baking soda/powder. Baking powder is composed of 30% of sodium bicarbonate, with cornstarch, sodium aluminium sulfate, calcium acid phosphate, and calcium sulfate [1]. Sodium bicarbonate may be an ingredient of folk remedies containing turpentine, castor oil, lemon and sugar. It is also added to mouthwashes and dentifrices to prevent dental...

Induction apnoea and the peripheral chemoreceptors.

The duration of apnoea following induction of anaesdiesia with thiopentone (4.5 tng/kg) was recorded in two groups of patients premedicated with morphine, atropine and droperidoL In one group patients were allowed to breathe air and in the other 100% oxygen for 8 minutes before induction of anaesthesia. The duration of apnoea was significantly longer in the pre-oxygenated group (P<0.005) thus i...

Sodium bicarbonate revisited.

Sodium-coupled bicarbonate transporters.

Together, the Na(+)-coupled HCO(3)(-) transporters and the AE family of anion exchangers (i.e., Cl-HCO3 exchangers) comprise the bicarbonate transporter (BT) superfamily. Virtually all BTs are important for the regulation of intracellular pH (pH(i)) in cells throughout the body. Specific BTs also play roles in cell-volume regulation, as well as for the transport of salt and/or acid-base equival...