Stimulation of Steroid Receptor Coactivator-3 (SRC-3) Gene Overexpression by a Positive Regulatory Loop of E2F1 and SRC-3
نویسندگان
چکیده
منابع مشابه
Overexpression of the nuclear receptor coactivator AIB1 (SRC-3) during progression of pancreatic adenocarcinoma.
PURPOSE The nuclear receptor coactivator amplified in breast cancer 1 (AIB1) was found to be amplified and overexpressed in breast and some other epithelial tumors. We have reported that expression of AIB1 is rate limiting for growth factor, as well as hormone signaling. Here, we assess the involvement of AIB1 in the development of pancreatic adenocarcinoma. EXPERIMENTAL DESIGN We investigate...
متن کاملSRC - 3 : a transcriptional coactivator and therapeutic target in cancer
Steroid receptor coactivator-3 (SRC-3), also known as amplified in breast cancer 1 (AIB1), a transcription coactivator, is frequently overexpressed in multiple type of human cancers, including breast, ovarian, prostate, pancreatic, lung, and colorectal cancers. SRC-3 not only interacts with multiple nuclear hormone receptors but also broad-spectrum of non-nuclear-receptor transcription factors ...
متن کاملBufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1.
Virtually all transcription factors partner with coactivators that recruit chromatin remodeling factors and interact with the basal transcription machinery. Coactivators have been implicated in cancer cell proliferation, invasion, and metastasis, including the p160 steroid receptor coactivator (SRC) family composed of SRC-1 (NCOA1), SRC-2 (TIF2/GRIP1/NCOA2), and SRC-3 (AIB1/ACTR/NCOA3). Given t...
متن کاملTissue- and gene-specific recruitment of steroid receptor coactivator-3 by thyroid hormone receptor during development.
Numerous coactivators that bind nuclear hormone receptors have been isolated and characterized in vitro. Relatively few studies have addressed the developmental roles of these cofactors in vivo. By using the total dependence of amphibian metamorphosis on thyroid hormone (T3) as a model, we have investigated the role of steroid receptor coactivator 3 (SRC3) in gene activation by thyroid hormone ...
متن کاملSRC-3 Has a Role in Cancer Other Than as a Nuclear Receptor Coactivator
Steroid receptor coactivator-3 (SRC-3), also known as AIB1, is a member of the p160 steroid receptor coactivator family. Since SRC-3 was found to be amplified in breast cancer in 1997, the role of SRC-3 in cancer has been broadly investigated. SRC-3 initially was identified as a transcriptional coactivator for nuclear receptors such as the estrogen receptor (ER), involved in the proliferation o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 2006
ISSN: 0888-8809,1944-9917
DOI: 10.1210/me.2005-0522