منابع مشابه
Nutrient detection by incretin hormone secreting cells
The hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulintropic polypeptide (GIP) are secreted after a meal. Like other enteroendocrine hormones they help to orchestrate the bodies' response to the availability of newly absorbable nutrients and are noteworthy as they stimulate postprandial insulin secretion, underlying what is known as the incretin effect. GLP-1-mimetics are no...
متن کاملdifferentiation of human embryonic stem cells into insulin- secreting cells
introduction: type i diabetes mellitus is caused by autoimmune destruction of the insulin-producing β-cells. a new potential method for curing the disease is transplantation of differentiated insulin- secreting cells from human embryonic stem cells. methods: human embryonic stem cell lines (royan h1) were used to produce embryoid bodies. differentiation carried out by growth factor-mediated sel...
متن کاملGpr40 Is Expressed in Enteroendocrine Cells and Mediates Free Fatty Acid Stimulation of Incretin Secretion
OBJECTIVE The G-protein-coupled receptor Gpr40 is expressed in beta-cells where it contributes to free fatty acid (FFA) enhancement of glucose-stimulated insulin secretion. However, other sites of Gpr40 expression, including the intestine, have been suggested. The transcription factor IPF1/PDX1 was recently shown to bind to an enhancer element within the 5'-flanking region of Gpr40, implying th...
متن کاملn-Secreting Cells
The T-type Ca + channel is an important determinant of electrical activity and of Ca + influx in rat and human pancreatic -cells. We have identified and sequenced a cDNA encoding a T-type Ca + channel 1s u b u n i t derived from INS-1, the rat insulin-secreting cell line. The sequence of the cDNA indicates a protein composed of 2,288 amino acids that shares 96.3% identity to 1G, the neuronal T-...
متن کاملImmunoglobulin Secreting Cells
(P < 0.02). The mean number of IgA secreting cells in bronchial lavage fluids was 633 per million lymphocytes as compared to 100 per million lymphocytes in peripheral blood (P < 0.005). Thus, compared to peripheral blood, cells from the lavage fluids were relatively enriched for both IgG and IgA secreting cells. However, IgA secreting cells were the major class of immunoglobulin secreting cells...
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ژورنال
عنوان ژورنال: Therapeutic Advances in Endocrinology and Metabolism
سال: 2015
ISSN: 2042-0188,2042-0196
DOI: 10.1177/2042018815618177