Stimulating Fungi <i>Pleurotus ostreatus</i> with Hydrocortisone

Fungi cells can sense extracellular signals via reception, transduction, and response mechanisms, allowing them to communicate with their host adapt environment. They feature effective regulatory protein expressions that enhance regulate adaptation various triggers such as stress, hormones, physical stimuli light, factors. In our recent studies, we have shown Pleurotus oyster fungi generate electrical potential impulses in the form of spike events exposure environmental, mechanical, chemical triggers, suggesting nature may be deduced from fungal responses. this study, explored communication protocols reporters human secretions addressing whether signals. We exposed hydrocortisone, which was directly applied surface a fungal-colonized hemp shavings substrate, recorded activity fungi. Hydrocortisone is medicinal hormone replacement similar natural stress cortisol. Changes cortisol levels released by body indicate presence disease detrimental effect on physiological process regulation. The hydrocortisone also further using X-rays reveal changes tissue, where receiving substrate inhibit flow calcium and, result, reduce its changes. This research could open way for future studies adaptive wearables capable detecting states biosensors built living