منابع مشابه
Plasmodium’s Sticky Fingers
The life cycle of the malaria parasite (Plasmodium) is remarkably complex. Malaria parasites must engage in highly specific and varied interactions with cell types of both the mammalian host and the mosquito vector. In this issue of Cell, report detailed molecular insights into an intimate interaction between a malaria parasite protein and its host cell receptor that enables the parasite to inv...
متن کاملSticky fingers for migration
Sticky fingers for migration R oaming cells send out sticky fi ngers to probe for good attachment points, say Catherine Galbraith, Kenneth Yamada, and James Galbraith (NIH, Bethesda, MD). The fi ngers’ sideways movements give cells a wider fi eld of vision than do forward and reverse movements alone. These sideways movements were picked up by the authors as ripples in the plasma membrane at the...
متن کاملTargeting the Sticky Fingers of HIV-1
Although human blood plasma contains molecules that inhibit the activity of HIV-1, their identity is largely unknown. Münch et al. (2007) now identify a peptide corresponding to a portion of alpha1-antitrypsin that potently inhibits entry of HIV-1 into host cells by binding to a hydrophobic segment of the viral envelope glycoprotein gp41.
متن کاملPrimary haemostasis: Sticky fingers cement the relationship
Platelet aggregation to form a haemostatic plug, or thrombus, plays a key role in preventing bleeding from a wound. Recent studies have provided new insights into how platelet receptors are deployed during the interactions with the vascular subendothelial matrix that lead to haemostatic plug formation.
متن کاملPeripheral membrane proteins: FYVE sticky fingers
The recently determined structure of the lipid-binding 'FYVE' domain provides several clues to the mode of interaction for this class of peripheral membrane proteins. However, the application of traditional modes of structural analysis to diffusible membrane-binding proteins exposes some limitations of these techniques.
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ژورنال
عنوان ژورنال: Nature
سال: 1998
ISSN: 0028-0836,1476-4687
DOI: 10.1038/28752