Sticking to the facts

Glue-sniffing and distal renal tubular acidosis: sticking to the facts.

An index case is presented to introduce the subject of the acid-base and electrolyte abnormalities resulting from toluene abuse. These include metabolic acidosis associated with a normal anion gap and excessive loss of sodium and potassium in the urine. The major question addressed is, what is the basis for the metabolic acidosis? Overproduction of hippuric acid resulting from the metabolism of...

Sticking to the nuclear envelope

mutation in torsinA, an AAA ATPase protein, causes DYT1 dystonia in humans. On page 855, Goodchild and Dauer identify two protein binding partners of torsinA, one that localizes to the ER membrane and one that spans the inner membrane of the nuclear envelope. The team hypothesizes that DYT1 is a nuclear envelope disease , and that identification of such protein complexes will provide a mechanis...

Sticking with Carrots and Sticks (Sticking Points Aside): A Response to Ventakapuram, Goldberg, and Forrow

Sticking to PIP2

Tucker, and Edwin Chapman (University of Wisconsin, Madison, WI) find that PIP 2 is a plasma membrane dock for synaptotagmin-1 (syt), a transmembrane protein localized in secretory vesicle membranes, when calcium is absent. This dock may ensure speedy and directed fusion in response to calcium influx. The syt dock has two calcium-binding domains in its cytoplasmic region, called C 2 A and C 2 B...

Sticking the Quantum Leap

Kurt Templeman is manager of enterprise networks at Sumitomo Electric Lightwave, Research Triangle Park, N.C. Contact him at ktempleman@ sumitomoelectric. com. Ranked in the top 100 “Most Wired” hospital systems in the country for seven consecutive years—an IT technology honor bestowed on just eight other hospitals in the country— Sharp Healthcare of San Diego is on a mission to revamp its Shar...