Stereotactic Administration of Edaravone Ameliorates Collagenase‐Induced Intracerebral Hemorrhage in Rat
نویسندگان
چکیده
منابع مشابه
Stereotactic Administration of Edaravone Ameliorates Collagenase‐Induced Intracerebral Hemorrhage in Rat
BACKGROUND Edaravone is widely used for treating ischemic stroke, but it is not still confirmed in intracerebral hemorrhage (ICH) as an ideal medication targeting the brain parenchyma. We aimed to investigate the neuroprotective effects of stereotactic administration of edaravone (SI) into the brain parenchyma. METHODS Intracerebral hemorrhage rat models were established by infusion of collag...
متن کاملTherapeutic Benefit of Intravenous Administration of Human Umbilical Cord Blood- Mononuclear Cells Following Intracerebral Hemorrhage in Rat
Objective(s) Human umbilical cord blood (HUCB) is now considered as a valuable source for stem cell–based therapies. Previous studies showed that intravascular injection of the HUCB significantly improves neurological functional recovery in a rat model of intracerebral hemorrhage (ICH). In the present study, we hypothesize transplanted HUCB derived mononuclear cells (UC-MCs) can decrease injur...
متن کاملEdaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhage.
BACKGROUND AND PURPOSE Our previous studies have demonstrated that oxidative DNA injury occurs in the brain after intracerebral hemorrhage (ICH). We therefore examined whether edaravone, a free-radical scavenger, could reduce ICH-induced brain injury. METHODS These experiments used pentobarbital-anesthetized, male Sprague-Dawley rats that received an infusion of either 100 microL autologous w...
متن کاملEffects and complications of stereotactic aspiration for spontaneous intracerebral hemorrhage.
Stereotactic aspiration of intracerebral hemorrhage (ICH) improves the general condition of patients, promotes improvement of consciousness, and decreases the incidence of pneumonia, but may induce rebleeding. The present study investigated the effects of stereotactic aspiration and factors that inhibit rebleeding in 70 consecutive patients who underwent stereotactic aspiration for ICH. Conscio...
متن کاملStereotactic Hematoma Removal of Spontaneous Intracerebral Hemorrhage through Parietal Approach
OBJECTIVE To determine the advantages of parietal approach compared to Kocher's point approach for spontaneous, oval-shaped intracerebral hemorrhage (ICH) with expansion to the parietal region. METHODS We divided patients into two groups : group A had burr holes in the parietal bone and group B had burr holes at Kocher's point. The hematoma volume, Glasgow coma scale (GCS) score, and modified...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: CNS Neuroscience & Therapeutics
سال: 2016
ISSN: 1755-5930,1755-5949
DOI: 10.1111/cns.12584