Stereoselective Synthesis of Alkylidene Phthalides

Pd/C-mediated synthesis of (Z)-3-alkylidene phthalides of potential pharmacological interest

Synthesis of Ru alkylidene complexes

The present work describes the robust synthesis of Ru alkylidene complexes (PCy(3))(2)Cl(2)Ru=CHR - precursors for metathesis catalysts. Moreover, the dynamic behavior of complexes where R = 2-naphthyl and 2-thienyl was studied. (1)H NMR techniques were employed to establish the preferred conformations in solution for both complexes and the energy barrier for rotation around single (Ru=)CH-C(th...

Stereoselective synthesis of (-)-spicigerolide.

(-)-Spicigerolide was stereoselectively synthesized from a protected (S)-lactaldehyde. The synthesis of the polyacetylated framework relied on two Zn-mediated stereoselective additions of alkynes to aldehydes as well as a regiocontrolled [3,3]-sigmatropic rearrangement of an allylic acetate. The pyranone moiety was constructed via ring-closing metathesis.

Mixed Acylais; Synthesis of Alkylidene Carboxylate Formates

Catalytic intramolecular ketone hydroacylation: enantioselective synthesis of phthalides.

The development of a new transition-metal-catalyzed transformation can often allow a traditional reaction, perhaps one that employs stoichiometric amounts of reagents and harsh reaction conditions, to be replaced by a selective, atom economic process which proceeds under mild reaction conditions. This is certainly the case with the recent report from Dong and co-workers of a catalytic enantiose...