Stereoselective Syntheses of Polysubstituted Olefins.
نویسندگان
چکیده
منابع مشابه
Stereoselective synthesis of polysubstituted piperazines and oxopiperazines. Useful building blocks in medicinal chemistry.
Many pharmaceutical agents include piperazines or oxopiperazines as part of their core structures. The presence of substituents on these heterocycles has a significant influence on the biological activity, thus the search for efficient routes to control the substitution at different ring positions might have a crucial impact, especially to promote the use of such scaffolds in SAR studies. Many ...
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Hydroxynitrile lyases (HNLs) from Prunus amygdalus (PaHNL), Sorghum bicolor (SbHNL), Manihot esculenta (MeHNL) and Hevea brasiliensis (HbHNL) are excellent biocatalysts for the preparation of optically active cyanohydrins. (R)as well as (S)-cyanohydrins are obtained in high optical and chemical yields. The synthetic potential of the now easily available optically pure cyanohydrins is demonstrat...
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The efficiency and stereoselectivity of the conjugate addition of lithium (Z)- or (E)-beta-amino ester enolates, generated by lithium amide conjugate addition to an alpha,beta-unsaturated ester or deprotonation of a beta-amino ester, respectively, to a range of alpha,beta-unsaturated acceptors has been investigated. Deprotonation of a beta-amino ester with LDA, followed by conjugate addition to...
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Four fluorescent non-natural aromatic amino acids have been synthesized based on a key stereoselective Michael addition reaction. S-1-phenylethylamine was employed as both the source of amine and the stereoselectivity controller. The overall yields were moderate (30-50%). Fluorescent properties of some of the fluorophores were also investigated. It was found that compounds with a dimethylamino ...
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ژورنال
عنوان ژورنال: Journal of Synthetic Organic Chemistry, Japan
سال: 1993
ISSN: 0037-9980,1883-6526
DOI: 10.5059/yukigoseikyokaishi.51.894