Stereoselective Mannich Reactions in the Synthesis of Enantiopure Piperidine Alkaloids and Derivatives

Abstract: Piperidine alkaloids are members of the alkaloid family that is characterized by presence a six-membered nitrogen-containing heterocycle. found mainly in plants and often exhibit interesting biological pharmacological activities. Despite accumulation these natural products plants, relatively low quantities produced absolute terms thus synthesis derivatives thereof remains relevant to identify targets for drug discovery. Throughout years, researchers have come up with myriad methods synthesize piperidine derivatives. This review describes employ stereoselective Mannich reactions create core alkaloids. Asymmetric induction reaction has been achieved range divided into three conceptual approaches: (1) chiral pool-based (internal asymmetric induction), (2) auxiliary-based (relayed induction) (3) catalysis-based (external induction). Of each approach, we describe mechanism rationalize stereochemical outcome products.