منابع مشابه
Enantioselective Catalysis Coupled with Stereodivergent Cyclization Strategies Enables Rapid Syntheses of (+)-Limaspermidine and (+)-Kopsihainanine A.
Enantioselective Pd-catalyzed allylic alkylations of dihydropyrido[1,2-a]indolone (DHPI) substrates were used to construct the C20-quaternary stereocenters of multiple monoterpene indole alkaloids. Stereodivergent Pictet-Spengler and Bischler-Napieralski cyclization/reduction cascades furnish the cis- and trans-fused azadecalin subunits present in Aspidosperma and Kopsia alkaloids, respectively...
متن کاملOxidant controlled regio- and stereodivergent azidohydroxylation of alkenes via I2 catalysis.
A novel, I2 catalyzed regio- and stereodivergent vicinal azidohydroxylation of alkenes leading to 1,2-azidoalcohols in high yields (up to 92%) and excellent dr (up to 98%) has been developed. This unprecedented transformation employs NaN3 and DMF as N- and O-nucleophiles respectively. The role of DMF as the O-source in the reaction has been unequivocally proven by (18)O labelling studies.
متن کاملStereodivergent Olefination of Enantioenriched Boronic Esters
A stereodivergent coupling reaction between vinyl halides and boronic esters is described. This coupling process proceeds without a transition-metal catalyst, instead proceeding by electrophilic selenation or iodination of a vinyl boronate complex followed by stereospecific syn or anti elimination. Chiral, nonracemic boronic esters could be coupled with complete enantiospecificity. The process ...
متن کاملCatalytic stereodivergent functionalization of H2@C60.
A complete stereocontrol of 1,3-dipolar cycloaddition of N-metalated azomethine ylides onto endohedral fullerene H2@C60 is reported for the first time. The stereodivergent synthesis of either the cis or the trans endohedral cycloadduct is achieved with excellent diastereo- and enantioselectivities.
متن کاملSequential stereodivergent organocatalysis and programmed organocascades.
Asymmetric organocatalysis has attracted great interest as a synthetic strategy during the past decade. But, although the inertness of organocatalysts to moisture and oxygen offers great opportunities to tune the reaction conditions, the stereoswitchable character of organocatalysts has not been systematically studied, and most findings have been serendipitous. In this Perspective, we emphasize...
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ژورنال
عنوان ژورنال: Chemical Reviews
سال: 2018
ISSN: 0009-2665,1520-6890
DOI: 10.1021/acs.chemrev.7b00561