Stereochemical Studies on a-Hydroxy Acids. I-II. I. Optical Resolutions of a-Hydroxy Acids

Studies on the in vitro antitumor activity of fatty acids. I. 10-Hydroxy-2-decenoic acid from royal jelly.

Whole royal jelly, when premixed with tumor cells before inoculation, has been shown to inhibit completely the development of transplantable AKR leukemia and of three lines of mouse ascitic tumors. Fractionation studies have established that all, or nearly all, of the in vitro antitumor activity of whole royal jelly can be accounted for in the major component of the ether-soluble fatty acid fra...

Poly(α-hydroxy Acids)-Based Cell Microcarriers

Biodegradable poly(α-hydroxyacids) have gained increasing interest in the biomedical field for their use as cell microcarriers thanks to their biodegradability, biocompatibility, tunable mechanical properties/degradation rates and processability. The synthesis of these poly(α-hydroxyacids) can be finely controlled to yield (co)polymers of desired mechanical properties and degradation rates. On ...

Alpha Hydroxy Acids in Cosmetic Dermatology

Monocyclic phenolic acids; hydroxy- and polyhydroxybenzoic acids: occurrence and recent bioactivity studies.

Among the wide diversity of naturally occurring phenolic acids, at least 30 hydroxy- and polyhydroxybenzoic acids have been reported in the last 10 years to have biological activities. The chemical structures, natural occurrence throughout the plant, algal, bacterial, fungal and animal kingdoms, and recently described bioactivities of these phenolic and polyphenolic acids are reviewed to illust...

Synthesis of Hydroxy Acids of Dinorcholane and 5β-Cholane

Enantiopure α-hydroxy acids (AHAs) are versatile building blocks in organic synthesis. They are used for obtaining pharmaceutically and biologically active substances, such as vitamins. α-Hydroxy acids are easily synthesized from cyanohydrins. Thus, molecules with cyanohydrin substructures are interesting intermediates for the synthesis of AHAs. Usually, cyanohydrins are prepared by the additio...