STATs get their move on

On the Move with All Their Senses

Pluripotency Factors on Their Lineage Move

Pluripotent stem cells are characterised by continuous self-renewal while maintaining the potential to differentiate into cells of all three germ layers. Regulatory networks of maintaining pluripotency have been described in great detail and, similarly, there is great knowledge on key players that regulate their differentiation. Interestingly, pluripotency has various shades with distinct devel...

Functional abdominal pain: time to get together and move forward.

Functional gastrointestinal disorders (FGID) include a combination of chronic or recurrent symptoms not explained by known biochemical or structural abnormalities. They represent a challenging group of conditions that are frequently misdiagnosed in children and are associated with significant morbidity and high health care costs. They account for more than 50% of the consultations in pediatric ...

Will jams get worse when slow cars move over ?

– Motivated by an analogy with traffic, we simulate two species of particles ('vehicles'), moving stochastically in opposite directions on a two-lane ring road. Each species prefers one lane over the other, controlled by a parameter 0 ≤ b ≤ 1 such that b = 0 corresponds to random lane choice and b = 1 to perfect 'laning'. We find that the system displays one large cluster ('jam') whose size inc...

Cytokines and Their STATs in Cutaneous and Visceral Leishmaniasis

Cytokines play a critical role in shaping the host immune response to Leishmania infection and directing the development of protective and non-protective immunities during infection. Cytokines exert their biological activities through the activation and translocation of transcription factors into the nucleus whether they drive the expression of specific cytokine-responsive genes. Signal transdu...