Statistics of Fragment Dispersion by Explosion in a Fragment Generator Warhead

An NMR-Guided Screening Method for Selective Fragment Docking and Synthesis of a Warhead Inhibitor.

Selective hits for the glutaredoxin ortholog of Brucella melitensis are determined using STD NMR and verified by trNOE and (15)N-HSQC titration. The most promising hit, RK207, was docked into the target molecule using a scoring function to compare simulated poses to experimental data. After elucidating possible poses, the hit was further optimized into the lead compound by extension with an ele...

Determination of Superficial Clefts on Fragment of Antigen Binding in Human Immunoglobulin G by Computational Immunology

Background: Immunoglobulins (Igs) are protective glycoproteins specifically identify and eradicate microbes. Fragment of antigen binding (Fab) is a portion of antibody which binds to antigen and consists of one variable and one constant domain of one heavy and one light chain. Idiotypes, epitopes situated on Igs variable region, could be exploited to monitor and target malignant B cells and are...

Identification of Avian Salmonella Isolates by PCR-RFLP Analysis of a fliC Gene Fragment

The genus of Salmonella is very polymorphic and comprised of a number of genetically closely related serotypes. It is one of the emerging pathogen in food-borne disease which is often found in contaminated chicken eggs. Salmonella enterica is considered one of the major pathogens in public health worldwide. A total of 31 Salmonella isolates identified by specific antisera, which included Salmon...

Orbitocranial penetration by a fragment of wood.

The Medical Journal of Australia ISSN: 0025729X 20 September 2004 181 6 329-330 ©The Medical Journal of Australia 2004 www.mja.com.au Lessons from practice Non-contrast computed tomography (CT) of the bra two minute areas of high density in the left frontal lobe, as evidence of early infection. CT of the orbits revealed swelling of the subcutaneous soft tissue, interpreted as cellulitis. A frac...

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