Statistical models for biphasic dose-response relationships (hormesis) in toxicological studies
نویسندگان
چکیده
منابع مشابه
Evidence for hormesis in mutagenicity dose-response relationships.
This study assessed the occurrence of hormetic dose responses from three previously published data sets [1-3] with 825 chemicals in three Ames assay tester strains (i.e., TA97, TA98, TA100) with and without the S9 fraction, using a five dose protocol and semi-log dose spacing. Ninety-five (95) (11.5%) chemicals satisfied the multiple a priori entry criteria, with a total of 107 assays. Of the a...
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Hormesis, a dose-response relationship phenomenon characterized by low-dose stimulation and high-dose inhibition, has been frequently observed in properly designed studies and is broadly generalizable as being independent of chemical/physical agent, biological model, and endpoint measured. This under-recognized and -appreciated concept has the potential to profoundly change toxicology and its r...
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Non-linear dose response relationships pose statistical challenges for their discovery. Even when an initial linear approximation is followed by other approaches, the results may be misleading and, possibly, preclude altogether the discovery of the nonlinear relationship under investigation. We review a variety of straightforward statistical approaches for detecting nonlinear relationships and ...
متن کاملHormesis and Its Place in Nonmonotonic Dose–Response Relationships: Some Scientific Reality Checks
OBJECTIVE This analysis is a critical assessment of current hormesis literature. I discuss definitions, characterization, generalizability, mechanisms, absence of empirical data specific for hormesis hypothesis testing, and arguments that hormesis be the "default assumption" in risk assessment. DATA SOURCES Hormesis, a biological phenomenon typically described as low-dose stimulation from sub...
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Environmentally mediated infectious disease transmission models provide a mechanistic approach to examining environmental interventions for outbreaks, such as water treatment or surface decontamination. The shift from the classical SIR framework to one incorporating the environment requires codifying the relationship between exposure to environmental pathogens and infection, i.e. the dose-respo...
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ژورنال
عنوان ژورنال: Ecotoxicology and Environmental Contamination
سال: 2017
ISSN: 2317-9643
DOI: 10.5132/eec.2017.01.06