Statistical evaluation of toxicological bioassays – a review
نویسندگان
چکیده
منابع مشابه
Statistical evaluation of toxicological bioassays – a review
The basic conclusions in almost all reports on new drug applications and in all publications in toxicology are based on statistical methods. However, serious contradictions exist in practice: designs with small samples sizes but use of asymptotic methods (i.e. constructed for larger sample sizes), statistically significant findings without biological relevance (and vice versa), proof of hazard ...
متن کاملPreliminary Toxicological Evaluation of the River Danube Using in Vitro Bioassays
The Joint Danube Survey 3, carried out in 2013 was the world’s biggest river research expedition of its kind. The course of the second largest river of Europe passes large cities like Vienna, Budapest and Belgrade and is fed from many tributaries like Inn, Thisza, Drava, Prut, Siret and Argeș. During the 6 weeks of shipping the 2375 km downstream the River Danube from Germany to the Black Sea a...
متن کاملA Review and Evaluation of Statistical Process Control Methods in Monitoring Process Mean and Variance Simultaneously
In this paper, first the available single charting methods, which have been proposed to detect simultaneous shifts in a single process mean and variance, are reviewed. Then, by designing proper simulation studies these methods are evaluated in terms of in-control and out-ofcontrol average run length criteria (ARL). The results of these simulation experiments show that the EWMA and EWMS methods ...
متن کاملA review on toxicological properties of thymoquinone a natural broad spectrum ingredient
Background and objectives: Nigella sativa is a delicate floral vegetable belonging to Ranunculaceae family. Thymoquinone (TQ) is the dominant active component in Nigella sativa seed oil which has a variety of pharmacological properties such as antioxidant, anticancer, anti-inflammatory and analgesic activities. However, TQ is a quinone derivative, which may le...
متن کاملStatistical approaches to toxicological data.
Statistical techniques as applied to toxicological data are discussed. Issues concerning statistical hypothesis testing and combining studies are considered as well as design of experiments. The problems surrounding risk assessment are also mentioned.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Toxicol. Res.
سال: 2014
ISSN: 2045-452X,2045-4538
DOI: 10.1039/c4tx00047a