Statistical Assessment of Proton Treatment Plans Under Setup and Range Uncertainties

Minimax optimization for handling range and setup uncertainties in proton therapy.

PURPOSE Intensity modulated proton therapy (IMPT) is sensitive to errors, mainly due to high stopping power dependency and steep beam dose gradients. Conventional margins are often insufficient to ensure robustness of treatment plans. In this article, a method is developed that takes the uncertainties into account during the plan optimization. METHODS Dose contributions for a number of range ...

etiology, significance, diagnosis and treatment of bruxiam

چکیده ندارد.

Assessment and Treatment of Uncertainties

Statistical uncertainty estimation in the calculation of the proton range in water phantom.

Introduction: GATE (Geant4 Application for Tomographic Emission) is a Monte Carlo simulation platform developed by the OpenGATE collaboration since 2001 and first publicly released in 2004. In Geant4, each physics process is described by a model (several models are sometimes available for a given physics process) and a corresponding cross-section table. All Geant4 physics model...

Dose uncertainties in IMPT for oropharyngeal cancer in the presence of anatomical, range, and setup errors.

PURPOSE Setup, range, and anatomical uncertainties influence the dose delivered with intensity modulated proton therapy (IMPT), but clinical quantification of these errors for oropharyngeal cancer is lacking. We quantified these factors and investigated treatment fidelity, that is, robustness, as influenced by adaptive planning and by applying more beam directions. METHODS AND MATERIALS We us...