منابع مشابه
To SWiTCH or not to SWiTCH?
In this issue of Blood, Ware and Helms report results from the Stroke With Transfusions Changing To Hydroxyurea (SWiTCH) study designed to determine whether hydroxyurea is as effective as transfusions in preventing recurrent strokes in children with sickle cell anemia. The finding of strokes in 7 of 67 children receiving hydroxyurea but none in 66 children who received transfusions led the auth...
متن کاملDirect oral anticoagulants: to switch or not to switch?
Fifty years after the introduction of vitamin K antagonists (VKAs) a novel group of oral anticoagulants has been introduced. The currently named direct oral anticoagulants (DOACs) represent a landmark in anticoagulant care. The direct factor Xa inhibitors (rivaroxaban, apixaban, edoxaban) and direct factor IIa inhibitors (dabigatran) are being prescribed more frequently, as both clinicians and ...
متن کاملInfliximab or biosimilars in sarcoidosis; to switch or not to switch?
Sarcoidosis is a systemic, granulomatous disorder that can affect multiple organs and has a variable clinical course (1). Because the etiology of sarcoidosis remains unknown, no curative treatment exists. It is important to state that not all patients require treatment. In the literature the need for systemic treatment varies between 20-70% (2-4). Main treatment indications are risk of organ fa...
متن کاملTo switch or not to switch: at the origin of repeat expansion disease.
Expansions of DNA repeats cause hereditary disorders in humans. Gerhardt et al. (2014) argue that a developmental switch in the direction of DNA replication through the (CGG)n repeat predisposes it to expansions during intergenerational transmissions leading to fragile X syndrome.
متن کاملTo Switch or Not To Switch: Understanding Social Influence in Recommender Systems
We designed and ran an experiment to test how often people’s choices are reversed by others’ recommendations when facing different levels of confirmation and conformity pressures. In our experiment participants were first asked to provide their preferences between pairs of items. They were then asked to make second choices about the same pairs with knowledge of others’ preferences. Our results ...
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ژورنال
عنوان ژورنال: Prescriber
سال: 2008
ISSN: 0959-6682,1931-2253
DOI: 10.1002/psb.221