Statins Do Not Directly Inhibit the Activity of Major Epigenetic Modifying Enzymes
نویسندگان
چکیده
منابع مشابه
Do Statins Inhibit Clopidogrel’s Antiplatelet Activity?
1 Pharmacy Times is proud to publish this new column on drug interactions by the esteemed Drs. Horn and Hansten, professors of pharmacy at the University of Washington and authors of the pocketsized drug interaction booklet The Top 100 Drug Interactions: A Guide to Patient Management and the loose-leaf reference Drug Interactions Analysis and Management. This column will appear monthly, and fee...
متن کاملThe aqueous extract of Triumfetta semitriloba (Tiliaceae) does not inhibit the in-vitro hydrolytic activity of the major pancreatic enzymes.
The aqueous extract of Triumfetta semitriloba is part of the Costa Rican folk pharmacopoeia. It shows no in-vitro inhibitory action on the hydrolytic activity of porcine pancreatic amylase, lipase or proteases, thus diminishing the concern of intestinal malabsorption in human beings.
متن کاملEpigenetic drugs that do not target enzyme activity.
While the installation and removal of epigenetic post-translational modifications or ‘marks’ on both DNA and histone proteins are the tangible outcome of enzymatically catalyzed processes, the role of the epigenetic reader proteins looks, at first, less obvious. As they do not catalyze a chemical transformation or process as such, their role is not enzymatic. However, this does not preclude the...
متن کاملBovine milk fat globules do not inhibit C5a chemotactic activity.
The C5a complement fragment is a potent inflammatory molecule but its contribution to the inflammatory response of the mammary gland remains uncertain. One of the unresolved questions is the possible interference of whole milk with C5a. In this study, the chemotactic activity ofpurifled bovine C5a was tested in the presence of whole or skimmed milk. Milk from healthy glands acted as a chemoattr...
متن کاملStatins Inhibit HIV-1 Infection by Down-regulating Rho Activity
Human immunodeficiency virus (HIV)-1 infectivity requires actin-dependent clustering of host lipid raft-associated receptors, a process that might be linked to Rho guanosine triphosphatase (GTPase) activation. Rho GTPase activity can be negatively regulated by statins, a family of drugs used to treat hypercholesterolemia in man. Statins mediate inhibition of Rho GTPases by impeding prenylation ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancers
سال: 2019
ISSN: 2072-6694
DOI: 10.3390/cancers11040516