منابع مشابه
Statins affect AQP2 traffic.
THE AQUAPORIN-2 WATER CHANNEL (AQP2) plays a critical role in mediating vaopressin action in the kidney collecting duct (4). Physiologically, vasopressin acts by activating the V2 receptor on the basolateral side of these cells to trigger a classical G proteincoupled activation cascade resulting in increased cAMP and activation of protein kinase A (PKA). With the realization that AQP2 transloca...
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The disabling pathophysiologic effects of lipid and neuroprotective effects of statins have recently been demonstrated for acute spinal cord injuries in animal models. This large scale population-based study aimed to investigate the effect hyperlipidemia and the use of statins in patients with lumbar spine injury. The National Health Insurance Research Database of Taiwan was used to identify pa...
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BACKGROUND Given the lack of consensus about the effect of traffic-derived pollutants on male fertility, we evaluated semen quality in men occupationally exposed to traffic. METHODS Semen quality was investigated in 85 men employed at motorway tollgates and in 85 age-matched men living in the same area. Semen, circulating sex hormones, methaemoglobin, sulphaemoglobin, carboxyhaemoglobin, lead...
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Negative binomial regression models were used to assess the effect of street and street network characteristics on total crashes, severe injury crashes, and fatal crashes. Data from over 230,000 crashes taking place over 11 years in 24 California cities was analyzed at the U.S. Census Block Group level of geography. In our analysis we controlled for variables such as vehicle volumes, income lev...
متن کاملBidirectional regulation of AQP2 trafficking and recycling: involvement of AQP2-S256 phosphorylation.
The present study examined the role of PKA and serine256 (S256) phosphorylation for AQP2 trafficking and recycling using cells transfected with wild-type AQP2 (AQP2-WT) or mutant AQP2 and high-resolution confocal microscopic techniques. In transiently transfected MDCK-C7 cells, stimulation with forskolin induced translocation of AQP2-WT to the plasma membrane. Treatment of AQP2-WT cells with th...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Renal Physiology
سال: 2011
ISSN: 1931-857X,1522-1466
DOI: 10.1152/ajprenal.00248.2011