STAT3exon 21 mutation is rare in common human cancers
نویسندگان
چکیده
منابع مشابه
Rare somatic mutation of pro-apoptotic BAX and BAK genes in common human cancers.
AIMS AND BACKGROUND BAX and BAK are both pro-apoptotic Bcl-2 proteins and are essential for the pathway of intrinsic apoptosis. Apoptosis in cancer cells is frequently inactivated by somatic mutations. The aim of the study was to see whether somatic mutations of BAX and BAK genes are characteristics of common human cancers. METHODS We analyzed somatic mutation of BAX and BAK genes in 47 gastr...
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We looked for mutations in the caveolin-1 gene, encoding a critical molecule for membrane signaling to cell growth, in 92 primary human breast cancers, and we report here the identification of a mutation in caveolin-1 at codon 132 (P132L) in 16% of cases. The mutation-positive cases were mostly invasive scirrhous carcinomas. In cell lines expressing the same mutant of caveolin-1, we observed th...
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ژورنال
عنوان ژورنال: Acta Oncologica
سال: 2013
ISSN: 0284-186X,1651-226X
DOI: 10.3109/0284186x.2013.758871