STAT3 in Skeletal Muscle Function and Disorders
نویسندگان
چکیده
منابع مشابه
Skeletal Muscle Na+ Channel Disorders
Five inherited human disorders affecting skeletal muscle contraction have been traced to mutations in the gene encoding the voltage-gated sodium channel Na(v)1.4. The main symptoms of these disorders are myotonia or periodic paralysis caused by changes in skeletal muscle fiber excitability. Symptoms of these disorders vary from mild or latent disease to incapacitating or even death in severe ca...
متن کاملSkeletal Muscle Function and Metabolism
Skeletal muscle consists of bundles of long spindle shaped cells called muscle fibers that attach to bone by tendinous insertions. The blood vessels and nerves that nourish and control muscle function run in thin sheets of connective tissue that surround bundles of muscle fibers. Each nerve branch communicates with one muscle fiber at the motor end. The nerve and all the muscle fibers that it s...
متن کاملSTAT3 Activation in Skeletal Muscle Links Muscle Wasting and the Acute Phase Response in Cancer Cachexia
BACKGROUND Cachexia, or weight loss despite adequate nutrition, significantly impairs quality of life and response to therapy in cancer patients. In cancer patients, skeletal muscle wasting, weight loss and mortality are all positively associated with increased serum cytokines, particularly Interleukin-6 (IL-6), and the presence of the acute phase response. Acute phase proteins, including fibri...
متن کاملLower limb skeletal muscle function
Berg, H. E., L. Larsson, and P. A. Tesch. Lower limb skeletal muscle function after 6 wk of bed rest. J. Appl. Physiol. 82(1): 182–188, 1997.—Force, electromyographic (EMG) activity, muscle mass, and fiber characteristics were studied in seven healthy men before and after 6 wk of bed rest. Maximum voluntary isometric and concentric knee extensor torque decreased (P , 0.05) uniformly across angu...
متن کاملCalpains, skeletal muscle function and exercise.
1. Skeletal muscle fibres contain ubiquitous (mu-calpain and m-calpain) and muscle-specific (calpain-3) Ca(2+)-dependent proteases. The physiological roles of the calpains are not well understood, although ubiquitous calpains have been associated with apoptosis and myogenesis and calpain-3 is likely involved in sarcomeric remodelling. A defect in the expression of calpain-3 results in limb-gird...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2018
ISSN: 1422-0067
DOI: 10.3390/ijms19082265