Starving the Devourer: Cutting Cancer Off from Its Favorite Foods
نویسندگان
چکیده
منابع مشابه
Cutting the head off chemokines
Chemokines are small secreted proteins that attract leukocyte migration. Chemokines play essential roles in the normal immune response against invading pathogens. Unfortunately, in an unregulated state they can also mediate abnormal leukocyte infiltration in ARDS, postinfarction damage, and multiple auto-immune diseases. In addition, chemokines or their receptors have also been subverted for ne...
متن کاملCutting the head off chemokines
Chemokines are small secreted proteins that attract leukocyte migration. Chemokines play essential roles in the normal immune response against invading pathogens. Unfortunately, in an unregulated state they can also mediate abnormal leukocyte infiltration in ARDS, postinfarction damage, and multiple auto-immune diseases. In addition, chemokines or their receptors have also been subverted for ne...
متن کاملCutting the head off chemokines
Chemokines are small secreted proteins that attract leukocyte migration. Chemokines play essential roles in the normal immune response against invading pathogens. Unfortunately, in an unregulated state they can also mediate abnormal leukocyte infiltration in ARDS, postinfarction damage, and multiple auto-immune diseases. In addition, chemokines or their receptors have also been subverted for ne...
متن کاملCutting off cancer's supply lines.
Targeting the blood vessels that feed tumours is not the silver bullet once hoped for, but refinements to the strategy may suggest further ways to treat the disease. Erika Check Hayden reports. Drugs that aim to choke off a tumour's blood supply, known as angiogenesis inhibitors, have been hailed as opening a new era in cancer therapy. But a flurry of animal studies suggests that such drugs may...
متن کاملStarving Cancer: a Study of Glutamine Dependency in Cancer Cells
This study examined glutamine dependency in cancer cells, where glutamine serves as the primary mitochondrial energy source. Effects of the protein cyclin D1 on glutamine metabolism were examined because cyclin D1 is a major driver of cancer-cell proliferation. Specific goals were 1) to find human cancer-cell lines that are glutamine dependent, 2) to knock down glutamine and overexpress cyclin ...
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ژورنال
عنوان ژورنال: Cell Chemical Biology
سال: 2019
ISSN: 2451-9456
DOI: 10.1016/j.chembiol.2019.09.005