Staphylococcal penicillinase and the new penicillins
نویسندگان
چکیده
منابع مشابه
Penicillinase-resistant Penicillins in the Treatment of Surgical Staphylococcal Infections.
although it has the advantage of being given orally, seems less effective, and ampicillin similarly. Comparative statistical evidence of the value of the various penicillins and of the antibiotics is not available, and would be difficult to obtain, but I have no personal doubt that at present in the acute infection methicillin and chloramphenical are the two most effective drugs. A major anxiet...
متن کاملPenicillinase - resistant Penicillins and Cephalosporins
The discovery of penicillinase-resistant penicillins is an important landmark in the history of antibacterial chemotherapy. Methicillin came into clinical use in 1960, and its value in the treatment of penicillin-resistant staphylococcal infection is now well established. The same is true of the isoxazolyl penicillins, oxacillin and cloxacillin, which came on to the scenes about a year later. N...
متن کاملSusceptibility of the "penicillinase-resistant" penicillins and cephalosporins to penicillinase of Staphylococcus aureus.
The activities of some semisynthetic penicillins and cephalosporins have been tested against clinical strains of Staphylococcus aureus. The apparent activity in vitro varies with the method of testing used. Determination of MICs using light inocula fails to detect the destructive effect of penicillinase on the antibiotic. This was, however, demonstrated reproducibly by the use of a technique in...
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Citri and Zyk (3) recently showed that the penicillinase of Bacillus cereus, on interaction with substrates, may yield conformational changes at the active site of the enzyme. Earlier studies by a number of investigators (1, 2, 4, 6, 8, 11) showed that penicillin analogues resistant to staphylococcal penicillinase, such as methicillin, may cause inactivation ofthe enzyme. In contrast, Richmond ...
متن کاملAntibacterial activity, penicillinase stability and inducing ability of different penicillins.
There are now a t least three main types of antibacterial activity shown by different penicillins-the ordinary penicillin G type, the type shown by methicillin active against penicillinase-producing staphylococci and the. ‘ broad spectrum ’ type of activity shown by a-aminobenzylpenicillin. The inducing capacity of different penicillins can be measured by the concentration required for maximal ...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1962
ISSN: 0006-2936
DOI: 10.1042/bj0830229