Standardized Molecular and Genetic Diagnosis of Medulloblastoma
نویسندگان
چکیده
منابع مشابه
Rapid diagnosis of medulloblastoma molecular subgroups.
PURPOSE Microarray studies indicate medulloblastoma comprises distinct molecular disease subgroups, which offer potential for improved clinical management. EXPERIMENTAL DESIGN Minimal mRNA expression signatures diagnostic for the Wnt/Wingless (WNT) and Sonic Hedgehog (SHH) subgroups were developed, validated, and used to assign subgroup affiliation in 173 tumors from four independent cohorts,...
متن کاملImaging, Diagnosis, Prognosis Rapid Diagnosis of Medulloblastoma Molecular Subgroups
Purpose:Microarray studies indicate medulloblastoma comprises distinct molecular disease subgroups, which offer potential for improved clinical management. Experimental Design: Minimal mRNA expression signatures diagnostic for the Wnt/Wingless (WNT) and Sonic Hedgehog (SHH) subgroups were developed, validated, and used to assign subgroup affiliation in 173 tumors from four independent cohorts, ...
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Medulloblastoma encompasses a group of aggressively growing cancers that arise either in the cerebellum or brain stem. They present primarily in children, with 80-85 % of medulloblastomas being diagnosed in patients of 16 years and younger. In adults, medulloblastomas are rare and account for less than 1 % of intracranial malignancies. Due to the low incidence of medulloblastoma in adults, the ...
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ژورنال
عنوان ژورنال: Japanese Journal of Neurosurgery
سال: 2015
ISSN: 0917-950X,2187-3100
DOI: 10.7887/jcns.24.436