Stage specificity of novel growth factor expression during development of proliferative vitreoretinopathy
نویسندگان
چکیده
منابع مشابه
Proliferative vitreoretinopathy.
PURPOSE. The migration, proliferation, differentiation, and adhesion of cells and other cellular functions are influenced by the surrounding extracellular matrix, in normal and wound-healing conditions. The matrix metalloproteinases (MMPs) are a family of enzymes that degrade and remodel the extracellular matrix and, thus, play a central role in the wound-healing process. Proliferative vitreore...
متن کاملThe Pathogeny of Proliferative Vitreoretinopathy.
Proliferative vitreoretinopathy (PVR) is the most important complication of rhegmatogenous retinal detachment (RRD) and the main cause of RRD surgery failure. This is a review of recent literature data, which concerns PVR pathogeny and risk factors. The occurrence of pre- and subretinal membranes is a consequence of retinal pigment epithelial cells activation and migration, with concomitant par...
متن کاملGenetic correlates of proliferative vitreoretinopathy.
The experienced retinal surgeon is familiar with the frustrating task of prognosticating and preventing/treating proliferative vitreoretinopathy (PVR) after retinal detachment (RD) surgery. The imperfection of long-described clinical models for predicting PVR leaves the surgeon questioning what underlying predispositions to PVR may exist. Rojas and colleagues provide insight into this question ...
متن کاملPlatelet-derived growth factor receptor kinase inhibitor AG1295 and inhibition of experimental proliferative vitreoretinopathy.
PURPOSE Receptor tyrosine kinase (RTK) activation is critical for growth factor-mediated cell proliferation. The present study was designed to determine the effect of tyrphostin AG1295, a selective blocker of platelet-derived growth factor (PDGF) RTK, on proliferative vitreoretinopathy (PVR) development. METHODS Rabbit conjunctival fibroblasts cells (1 x 10(4)) were seeded into 96-well plates...
متن کاملApoptosis in proliferative vitreoretinopathy.
PURPOSE To study the involvement of apoptosis using different apoptosis markers in PVR pathogenesis. METHODS The presence of mRNA coding for Fas, Fas ligand (FasL), and TNF-related apoptosis inducing ligand (TRAIL) was investigated in vitreous samples from 46 consecutive patients-25 with PVR, 11 with retinal detachment (RD) not complicated by PVR, and 10 with macular hole (MH)-using RT-PCR. F...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Eye
سال: 2006
ISSN: 0950-222X,1476-5454
DOI: 10.1038/sj.eye.6702169