Stage-dependent expression of PI3K/Akt-pathway genes in neuroblastoma

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Stage-dependent expression of PI3K/Akt‑pathway genes in neuroblastoma.

The phosphoinositide-3 kinase (PI3K) pathway plays a critical role in cancer cell growth and survival and has also been implicated in the development of the childhood cancer neuroblastoma. In neuroblastoma high mRNA expression of the PI3K catalytic isoform PIK3CD is associated to favorable disease. Yet, activation of Akt is associated with poor pr...

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ژورنال

عنوان ژورنال: International Journal of Oncology

سال: 2012

ISSN: 1019-6439,1791-2423

DOI: 10.3892/ijo.2012.1732