Stacked stem cell sheets enhance cell-matrix interactions

Cell–cell and cell–matrix interactions

Roles of cell protrusions as initial and dynamic mediators of cell–cell and cell–ECM interactions Filopodia have well-established roles in sampling the local environment and making initial cell–ECM contacts at the leading edge of many cell types. Filopodial-like structures, termed “epithelial zippers,” can mediate initial contacts between epithelial cells that culminate in assembly of cell–cell...

Cell–cell and cell–matrix interactions

Intracellular interactions shape cells Intestinal epithelial cells build a brush border of microvilli at their apical surfaces that mediates nutrient absorption and host defense. Scott Crawley (Tyska Laboratory, Vanderbilt University Medical Center) showed that brush border assembly is driven by trans interactions between protocadherin-24 and mucin-like protocadherin at the tips of adjacent mic...

Creation of mouse embryonic stem cell-derived cardiac cell sheets.

Research on heart tissue engineering is an exciting and promising area. Although we previously developed bioengineered myocardium using cell sheet-based tissue engineering technologies, the issue of appropriate cell sources remained unresolved. In the present study, we created cell sheets of mouse embryonic stem (ES) cell-derived cardiomyocytes after expansion in three-dimensional stirred suspe...

Stem Cells and Cell-Matrix Interactions P4.1 Oral presentation The integrin α2β1 engagement in endothelial cell-matrix interactions

During the process of angiogenesis, endothelial cells (ECs) sprout into the collagen scaffold of the interstitial stroma [1, 2]. Collagen-binding integrins play a crucial role in this process [3]. Integrin α 2 β 1 is the principal collagen-binding receptor on ECs. It plays essential roles in elementary cell functions such as adhesion, cell shape, motility, proliferation , gene activation, and d...

P-92: Retinoic Acid and STO Co-Culture System Enhance Mouse Embryonic Stem Cell