Stable isotopes in obesity research

Stable isotopes in clinical research: safety reaffirmed.

Approaching half a century of stable-isotope usage in human metabolic studies has been without documented significant adverse effect. Side-effects with acute D dosing are transitory with no demonstrated evidence of permanent deleterious action. The threshold of D toxicity has been defined in animals and is far in excess of concentrations conceivably used in human studies. The possibility that D...

Recent highlights in biosynthesis research using stable isotopes

The long and successful history of isotopic labeling experiments within natural products research has both changed and deepened our understanding of biosynthesis. As demonstrated in this article, the usage of isotopes is not at all old-fashioned, but continues to give important insights into biosynthetic pathways of secondary metabolites. This review with 85 cited references is structured by se...

The use of stable isotopes in biological and medical research.

The use of stable isotopes for diagnosis and clinical research.

Stable, non-radioactive isotopes, so long overshadowed by radionuclides, have recently become much more widely used in clinical science. This renewed interest has been stimulated by improvements both in the increased availability and diversity of stable-isotopelabelled compounds and in mass-spectrometric methods for their quantitative analysis. In addition, there is an increasing awareness of t...

Stable isotopes in tree rings

Stable isotopes in tree rings could provide palaeoclimate reconstructions with perfect annual resolution and statistically defined confidence limits. Recent advances make the approach viable for non-specialist laboratories. The relevant literature is, however, spread across several disciplines, with common problems approached in different ways. Here we provide the first overview of isotope dend...