Stabilization of D-Amino Acid Oxidase via Covalent Immobilization and Mathematical Model of D-Methionine Oxidative Deamination Catalyzed by Immobilized Enzyme

Stabilization of D-Amino Acid Oxidase via Covalent Immobilization and Mathematical Model of D-Methionine Oxidative Deamination Catalyzed by Immobilized Enzyme

D-Amino acid oxidases (DAAOs) have an important role in several processes of interest in the fine chemical and pharmaceutical industry for drug discovery. They are used in the production of optically pure L-amino acids1 and unnatural amino acids2, and the production of 7-aminocephalosporanic acid (7-ACA)2,3 which is a precursor of antibiotics with annual demand of approximately 100 t worldwide3...

Biological role of D-amino acid oxidase and D-aspartate oxidase. Effects of D-amino acids.

D-Amino acids administered to animals are absorbed by the intestine and transported through the blood-stream to solid tissues where they are oxidized in vivo by D-amino acid oxidase and D-aspartate oxidase to produce the same compounds they do in vitro; i.e. NH3, H2O2, and the keto acid corresponding to the amino acid ingested. In the liver and kidneys of the animals, an inverse relationship ex...

Astudyon D-amino-acid Oxidase

amplification and cloning of d- amino acid oxidase; the enzyme catalyzes the antibiotic cephalosporin c to 7- amino cephalosporanic acid

INHIBITION OF THE d-AMINO ACID OXIDASE BY BENZOIC ACID

Benzoic acid has been reported to inhibit the oxidation of succinic acid by muscle (l), the oxidation of butyric acid and crotonic acid by liver slices (2), and the oxidation of acetoacetic acid by kidney slices (3). It has also been reported to inhibit the oxygen uptake of liver and kidney slices, diaphragm, minced liver, kidney, and brain (4). In the present work it was found that benzoic aci...