Stability of Self-Assembled Polymeric Micelles in Serum
نویسندگان
چکیده
منابع مشابه
Stability of Self-Assembled Polymeric Micelles in Serum
The stability of polymeric nanoparticles in serum is critical to their use in drug delivery where dilution after intravenous injection often results in nanoparticle disassembly and drug unloading; however, few investigate this in biologically relevant media. To gain greater insight into nanoparticle stability in blood, the stability of self-assembled polymeric micelles of poly(d,l-lactide-co-2-...
متن کاملPolymeric Nanostructures as Colloidal Drug Delivery Systems: Thermosensitive Hydrogels Containing Self-Assembled Micelles
Polymeric nanostructures for drug delivery applications including smart hydrogels and stealth micelles have been developed to overcome many obstacles in the way of timing and targeting the delivery to fulfill therapeutic potentiality of chemicals. The purpose of this investigation is to prepare and characterize novel nanoparticle-based colloidal products composed of biocompatible polymers to us...
متن کاملTopochemical polymerization in self-assembled rodlike micelles of bisurea bolaamphiphiles.
Rod-like micelles, formed from bolaamphiphiles with oligo(ethylene oxide) hydrophilic outer segments and a hydrophobic segment with diacetylene flanked by two urea moieties, were covalently fixated by topochemical photopolymerization to high degrees of polymerization by optimizing the hydrophobic core and the hydrophilic periphery of the bolaamphiphiles. Analysis of the polymerized product with...
متن کاملChaotropic-anion-induced supramolecular self-assembly of ionic polymeric micelles.
Traditional micelle self-assembly is driven by the association of hydrophobic segments of amphiphilic molecules forming distinctive core-shell nanostructures in water. Here we report a surprising chaotropic-anion-induced micellization of cationic ammonium-containing block copolymers. The resulting micelle nanoparticle consists of a large number of ion pairs (≈60,000) in each hydrophobic core. U...
متن کاملDiscrete and polymeric self-assembled dendrimers: hydrogen bond-mediated assembly with high stability and high fidelity.
Hydrogen bond-mediated self-assembly is a powerful strategy for creating nanoscale structures. However, little is known about the fidelity of assembly processes that must occur when similar and potentially competing hydrogen-bonding motifs are present. Furthermore, there is a continuing need for new modules and strategies that can amplify the relatively weak strength of a hydrogen bond to give ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Macromolecules
سال: 2011
ISSN: 0024-9297,1520-5835
DOI: 10.1021/ma200675w