Stability of proteins encapsulated in injectable and biodegradable poly(lactide-co-glycolide)-glucose millicylinders
نویسندگان
چکیده
منابع مشابه
Structural and functional characterization of proteins adsorbed on hydrophilized polylactide-co-glycolide microfibers
BACKGROUND Hydrophobic biopolymers such as polylactide-co-glycolide (PLGA, 85:15) have been extensively explored as scaffolding materials for tissue engineering applications. More recently, electrospun microfiber-based and nanofiber-based scaffolds of PLGA have received increased attention because they act as physical mimics of the fibrillar extracellular matrix. However, the hydrophobicity of ...
متن کاملPolylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents
The effectiveness of anticancer agents may be hindered by low solubility in water, poor permeability, and high efflux from cells. Nanomaterials have been used to enable drug delivery with lower toxicity to healthy cells and enhanced drug delivery to tumor cells. Different nanoparticles have been developed using different polymers with or without surface modification to target tumor cells both p...
متن کاملPolylactide-co-glycolide fiber-reinforced calcium phosphate bone cement.
OBJECTIVE To compare the strength of polylactide-co-glycolide fiber-reinforced calcium phosphate bone cement (FRC) with nonreinforced calcium phosphate bone cement (NRC) subjected to simulated dural pulsations in defects larger than 25 cm(2). METHODS Seven NRC and 7 FRC specimens were set in both medium (37.5 cm(2)) and large (50.0 cm(2)) model skull defects while subjected to simulated dural...
متن کاملBiodegradable polylactide/montmorillonite nanocomposites.
Our continuing research on the preparation, characterization, materials properties, and biodegradability of polylactide (PLA)/organically modified layered silicate (OMLS) nanocomposites has yielded results on PLA/montmorillonite nanocomposites. Montmorillonite (mmt) modified with dimethyldioctadecylammonium cation was used as an OMLS for nanocomposite preparation. The internal structure of nano...
متن کاملImparting Superhydrophobicity to Biodegradable Poly(lactide-co-glycolide) Electrospun Meshes
The synthesis of a family of new poly(lactic acid-co-glycerol monostearate) (PLA-PGC18) copolymers and their use as biodegradable polymer dopants is reported to enhance the hydrophobicity of poly(lactic acid-co-glycolic acid) (PLGA) nonwoven meshes. Solutions of PLGA are doped with PLA-PGC18 and electrospun to form meshes with micrometer-sized fibers. Fiber diameter, percent doping, and copolym...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutics
سال: 2008
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2008.02.004