Stability-Indicating HPLC Method for Posaconazole Bulk Assay
نویسندگان
چکیده
منابع مشابه
Stability-Indicating HPLC Method for Posaconazole Bulk Assay
A stability-indicating liquid chromatographic (LC) method was developed for the determination of posaconazole in bulk. Chromatographic separation was achieved using an isocratic elution in a reversed-phase system, with a mobile phase composed of methanol-water (75:25, v/v), at 1.0 mL min(-1) flow. Samples were exposed to degradation under thermal, oxidative and acid/basic conditions, and no int...
متن کاملA Validated Stability-Indicating HPLC Assay Method for Cetrizine HCl in Bulk Drug
An isocratic reversed phase stability-indicating high-performance liquid chromatographic (HPLC) assay method was developed and validated for quantitative determination of Cetrizine hydrochloride in bulk drugs. An isocratic, reversed phase HPLC method was developed to separate the drug from the degradation products, using an Thermo Hypersil C18 (250 x 4.6)mm,5μ column and the mobile phase contai...
متن کاملA Validated Stability-Indicating HPLC Assay Method for Flucytosine in Bulk Drug
An isocratic reversed phase stability-indicating high-performance liquid chromatographic (HPLC) assay method was developed and validated for quantitative determination of Flucytosine in bulk drugs. An isocratic, reversed phase HPLC method was developed to separate the drug from the degradation products, using a Water Nova Pack C18 (250 x 4.6) mm, 5μ column and the mobile phase containing 1.0gm ...
متن کاملA Stability-Indicating RP-HPLC Assay Method for 5-Fluorouracil
The present study describes the development of a validated RP-HPLC method for the determination of 5-fluorouracil in presence of its degradation products or other pharmaceutical excipients. Stress studies were performed on 5-fluorouracil and it was found that it degrades sufficiently in alkaline conditions, while negligible degradation was observed in acidic, neutral, oxidative and photolytic c...
متن کاملStability-indicating HPLC Assay Method and Degradation Profile of Tamsulosin
A sensitive, stability-indicating liquid-chromatographic method for analysis of tamsulosin in the presence of its degradation products has been developed and validated. Efficient chromatographic separation was achieved on a C18 column with a simple isocratic mobile phase consisting methanol: 50 mM phosphate buffer (pH 7.8, ratio 80:20) at a flow rate of 1 ml/m. The linearity of the method was e...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientia Pharmaceutica
سال: 2012
ISSN: 0036-8709,2218-0532
DOI: 10.3797/scipharm.1111-11