SSR182289A enhances thrombolysis induced by fibrinolytic agents in rabbit models of venous and arterial thrombosis
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چکیده
منابع مشابه
A Rare Presentation of Arterial Thrombosis after Venous Thrombosis in a Patient with Gastric Cancer
Background: Venous thromboembolism, which comprises deep vein thrombosis and pulmonary embolism and is a significant cause of morbidity and mortality among patients with cancer. The aim of the present study was to report a rare presentation of arterial thrombosis after venous thrombosis in a patient with gastric cancer. Report of the Case: A 45 year-old female patient with locally advanced gas...
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Thromboembolic events represent the main cause of morbidity and mortality in patients with polycythemia vera. Leukocytosis has been identified as an important risk factor for development of vascular thrombosis. A 47-year-old woman with polycythemia vera presented with pain and swelling in her right calf. She was scheduled to receive anagrelide which was effective on polycythemia and thrombocyto...
متن کاملFibrinolytic therapy and deep venous thrombosis.
SIR,-Further to the interesting leading article "Nutrition and Sleep" (20 May, p. 418) one may ask whether sleep is not the "natural" state and wakefulness merely a res,pite for the satisfaction of instinctual (and socially inculcated) drives. The hibernating animal is unlikely to chance upon dangerous predators. On this model the satisfqction of drives would lead to sleep and their continued f...
متن کاملAntithrombotic properties of SSR182289A, a new, orally active thrombin inhibitor.
N-[3-[[[(1S)-4-(5-Amino-2-pyridinyl)-1-[[4-difluoromethylene)-1-piperidinyl]carbonyl]butyl]amino]sulfonyl][1,1'-biphenyl]-2-yl]acetamide hydrochloride (SSR182289A) is a novel, potent, and selective thrombin inhibitor. We have examined the antithrombotic properties of SSR182289A administered by i.v. and p.o. routes in several different animal thrombosis models in comparison with reference antith...
متن کاملEndovascular thrombolysis in deep cerebral venous thrombosis.
We present two cases of acute thrombosis of the internal cerebral veins, vein of Galen, and straight sinus without sagittal sinus involvement. Both patients had hydrocephalus and severe edema of the basal ganglia and thalami, one with hemorrhagic infarction of the thalamus. Because both patients rapidly deteriorated to a comatose state, endovascular thrombolysis was performed with urokinase inf...
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ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2004
ISSN: 1538-7933,1538-7836
DOI: 10.1111/j.1538-7836.2004.00687.x