SRT1720, a sirtuin 1 activator, attenuates organ injury and inflammation in sepsis
نویسندگان
چکیده
منابع مشابه
Sirtuin 2 Regulates Microvascular Inflammation during Sepsis
Objective. Sepsis and septic shock, the leading causes of death in noncoronary intensive care units, kill more than 200,000/year in the US alone. Circulating cell-endothelial cell interactions are the rate determining factor in sepsis inflammation. Sirtuin, a seven-member family of proteins (SIRT1-7), epigenetically controls inflammation. We have studied the roles of SIRTs 1, 3, and 6 in sepsis...
متن کاملCorrection: Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice
[This corrects the article DOI: 10.1371/journal.pone.0160431.].
متن کاملSirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice
OBJECTIVE Obesity increases morbidity and resource utilization in sepsis patients. Sepsis transitions from early/hyper-inflammatory to late/hypo-inflammatory phase. Majority of sepsis-mortality occurs during the late sepsis; no therapies exist to treat late sepsis. In lean mice, we have shown that sirtuins (SIRTs) modulate this transition. Here, we investigated the role of sirtuins, especially ...
متن کاملEffects of Continuous Erythropoietin Receptor Activator in Sepsis-Induced Acute Kidney Injury and Multi-Organ Dysfunction
BACKGROUND Despite advances in supportive care, sepsis-related mortality remains high, especially in patients with acute kidney injury (AKI). Erythropoietin can protect organs against ischemia and sepsis. This effect has been linked to activation of intracellular survival pathways, although the mechanism remains unclear. Continuous erythropoietin receptor activator (CERA) is an erythropoietin w...
متن کاملReceptor-interacting protein kinase 3 deficiency inhibits immune cell infiltration and attenuates organ injury in sepsis
INTRODUCTION Sepsis is defined as a systemic hyper-inflammatory immune response, with a subsequent immune-suppressive phase, which leads to multiple organ dysfunction and late lethality. Receptor-interacting protein kinase 3 (RIPK3)-dependent necrosis is implicated in driving tumor necrosis factor alpha (TNF-α)- and sepsis-induced mortality in mice. However, it is unknown if RIPK3 deficiency ha...
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ژورنال
عنوان ژورنال: Journal of Surgical Research
سال: 2017
ISSN: 0022-4804
DOI: 10.1016/j.jss.2017.06.031