SRSF3 recruits DROSHA to the basal junction of primary microRNAs
نویسندگان
چکیده
منابع مشابه
Molecular Basis for the Recognition of Primary microRNAs by the Drosha-DGCR8 Complex
The Drosha-DGCR8 complex initiates microRNA maturation by precise cleavage of the stem loops that are embedded in primary transcripts (pri-miRNAs). Here we propose a model for this process that is based upon evidence from both computational and biochemical analyses. A typical metazoan pri-miRNA consists of a stem of approximately 33 bp, with a terminal loop and flanking segments. The terminal l...
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15 صفحه اولDrosha in primary microRNA processing.
MicroRNA (miRNA)-mediated gene silencing is one of the major regulatory pathways in eukaryotes. Much effort has been made to identify the factors involved in the pathway, and our understanding of RNA silencing has significantly advanced in recent years. Our group has been working on some of the issues regarding miRNA biogenesis and, in this paper, we summarize what we and other workers in the f...
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Affiliation: Graduate Institute of Life Science, National Defense Medical Center, Taipei 115, Taiwan Genomics Research Center, Academia Sinica, Taipei 115, Taiwan 3 PNN technologies Inc, Woodbridge, VA 22195, USA Department of Pediatrics/Hematology-Oncology, University of California San Diego Medical Center, CA 92103-8447, USA Children's Oncology Group Statistics and Data Center, University of ...
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ژورنال
عنوان ژورنال: RNA
سال: 2018
ISSN: 1355-8382,1469-9001
DOI: 10.1261/rna.065862.118