Srebf1 Controls Midbrain Dopaminergic Neurogenesis
نویسندگان
چکیده
منابع مشابه
Midbrain dopaminergic neurogenesis and behavioural recovery in a salamander lesion-induced regeneration model.
Death and lack of functional regeneration of midbrain dopaminergic (DA) neurons, decreased DA input in the target striatum and movement anomalies characterise Parkinson's disease (PD). There is currently no cure for PD. One way to promote recovery would be to induce or enhance DA neurogenesis. Whether DA neurogenesis occurs in the adult midbrain is a matter of debate. Here, we describe the crea...
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Loss of midbrain dopaminergic (mDA) neurons underlies the motor symptoms of Parkinson's disease. Towards cell replacement, studies have focused on mechanisms underlying embryonic mDA production, as a rational basis for deriving mDA neurons from stem cells. We will review studies of β-catenin, an obligate component of the Wnt cascade that is critical to mDA specification and neurogenesis. mDA ne...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2020
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2020.107601