Square-pyramidal mononuclear, dinuclear and polymeric copper(II) complexes with (2-pyridinylmethyl)amino derivatives

The coordination behavior of three ligand precursors 2-[(2- pyridinylmethyl)amino]acetic acid hydrochloride, 4-[(2- pyridinylmethyl)amino]benzoic hydrochloride and 4-{[2-(pyridin-2- ylmethylamino)ethylamino]methyl}benzoic HL1?HCl- HL3?HCl, respectively, in copper(II) complexes is described. were characterized by elemental analysis, ESI mass spectrometry IR spectroscopy, as well X-ray structural analysis. reaction with HL1?HCl methanol afforded the polymeric complex [{Cu(?-Cl)2(MeL1- ?2N,N?)}n] (1) featuring methyl ester L1 (MeL1). With HL2?HCl or dimeric [{CuCl(?-Cl)(HL2-?2N,N?)}2] (2) mononuclear [CuCl2(HL3-?3N,N?,N??)] (3) obtained. All exhibited square-pyramidal geometries. In 1, chains are formed through bridging chlorido ligands without typical hydrogen bonding interaction. Contrarily, COOH group 2 participating formation intermolecular forming a supramolecular structure. 3, (Cl?O) leads to 1-D diminished viability human 8505C, MCF-7, 518A2 SW480 cell lines. tumoricidal effect was realized mainly caspase-mediated apoptosis.