منابع مشابه
Sporadic Parkinsonism
Background Differential diagnosis of parkinsonian sindrome is a major challenge in movement disorders because at the onset there is an overlapping of signs and syntoms. From a neuropathological point of view, parkinsonism may be related to a degeneration of the nigrostriatal pathway or the neurodegenerative process may be more widespread [1,2]. In the early course of the a disease presenting wi...
متن کاملPINK1 mutations are associated with sporadic early-onset parkinsonism.
We have recently reported homozygous mutations in the PINK1 gene in three consanguineous families with early-onset parkinsonism (EOP) linked to the PARK6 locus. To further evaluate the pathogenic role of PINK1 in EOP and to draw genotype-phenotype correlates, we performed PINK1 mutation analysis in a cohort of Italian EOP patients, mostly sporadic, with onset younger than 50 years of age. Seven...
متن کاملStriatal Dopaminergic Functioning in Patients with Sporadic and Hereditary Spastic Paraplegias with Parkinsonism
Sporadic spastic paraplegia (SSP) and hereditary spastic paraplegia (HSP) belong to a clinical and genetically heterogeneous group of disorders characterized by progressive spasticity and weakness in the lower extremities. The symptoms are associated with pyramidal tract dysfunction and degeneration of the corticospinal tracts. Parkinsonism is uncommon in SSP/HSP patients. However, both disorde...
متن کاملStriatal and cortical pre- and postsynaptic dopaminergic dysfunction in sporadic parkin-linked parkinsonism.
To investigate striatal and cortical pre- and postsynaptic dopaminergic function in parkin-linked parkinsonism, 13 unrelated patients homozygous or compound heterozygous for parkin mutations were studied with [(18)F]dopa and [(11)C]raclopride (RAC) PET. Data were compared with a young-onset Parkinson's disease (YOPD) cohort, matched for age, disease severity and duration, but negative for parki...
متن کاملSymptomatic Parkinsonism.
Parkinson's disease, 'paralysis agitans', is characterized by a number of abnormalities. A similar clinical picture may be symptomatic of other disturbances: these are briefly described and the differential diagnosis is discussed.
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ژورنال
عنوان ژورنال: BMC Geriatrics
سال: 2010
ISSN: 1471-2318
DOI: 10.1186/1471-2318-10-s1-l40