Sporadic colorectal cancer – factors modulating individual susceptibility to cancer
نویسندگان
چکیده
منابع مشابه
environmental factors associated with sporadic colorectal cancer
background: today, cancer is one of the major health problems worldwide, and the importance of this disease in our country is growing. this cancer is the third cause of death and accounts for the second largest group of non-transmissible chronic diseases. colorectal cancer is the most common gastrointestinal cancer and includes 10% of deaths from cancer around the world. different genetic and ...
متن کاملamino acid substitution polymorphisms of two dna methyltransferases and susceptibility to sporadic colorectal cancer
aim : to evaluate the association of dnmt1 and mgmt amino acid substitution polymorphisms and colorectal cancer in iranian population. background : the mgmt and dnmt1 are two important methyltransferase enzymes. amino acid substitution polymorphisms in mgmt and dnmt1 genes may be associated with the genetic susceptibility to sporadic colorectal cancer. patients and methods : we assessed eight ...
متن کاملEffects of amino acid substitution polymorphisms of two DNA methyltransferases on susceptibility to sporadic colorectal cancer.
BACKGROUND AND AIM The present study was designed to consider whether amino acid substitution polymorphisms in O6-methylguanine-DNA methyltransferase (MGMT) and DNA methyl transferase 1 (DNMT1) genes may be associated with the genetic susceptibility to sporadic colorectal cancer. PATIENTS AND METHODS We assessed eight non-synonymous polymorphisms of these two genes by PCR/pyrosequencing. Our ...
متن کاملreverse association between mthfr polymorphism (c677t) with sporadic colorectal cancer
aim : to investigate association between mthfr gene polymorphism with colorectal cancer. background : the enzyme 5,10-methylene-tetrahydrofolate reductase (mthfr) is linked to dna methylation, synthesis and repair. one of the most important polymorphisms that has been identified in the mthfr gene is c677t. the single nucleotide polymorphism c677t has been found to be associated with decreased e...
متن کاملColorectal Cancer and Prevention
سرطان کولون و رکتوم یکی از انواع شایع - سابقه ابتلا به سرطان کولورکتال یا پولیپ های سرطانهاست که با وجود ایجاد مشکلات و عوارض متعدد در سلامتی انسانها، هنوز به طور جدی و کافی مورد توجه قرار نگرفته است. به طوریکه در سال ۲۰۰۴ بیش از ۱۳۰ هزار مورد جدید ابتلا به این بیماری در امریکا گزارش شده است. و طبق آمارهای انجمن سرطان آمریکا در سال ۲۰۰۲، از ۱۸۳۳۰۰ مورد ابتلا به سرطان کولورکتال۵۶ هزار مورد ب...
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ژورنال
عنوان ژورنال: Współczesna Onkologia
سال: 2010
ISSN: 1428-2526
DOI: 10.5114/wo.2010.14132