SPONTANEOUS VARIATIONS IN RENAL HANDLING OF URIC ACID: 164
نویسندگان
چکیده
منابع مشابه
Renal handling of uric acid in man.
The uricosuric response to 80 mg of micronized Benzbromarone was employed to assess the renal tubular secretory site for uric acid in patients with primary gout. Since Benzbromarone selectively inhibits tubular reabsorption of secreted urate, the maximum uricosuria induced by this drug can be equated with the minimal secretory rate. Furthermore, a significant relationship was noted in normal co...
متن کاملEffects of angiotensin II receptor blockers on renal handling of uric acid in rats.
Elevated serum uric acid level has been associated with increased cardiovascular risk in hypertensive patients. Several angiotensin II receptor blockers exhibit differential effects on regulation of serum uric acid level in humans. We have demonstrated that some angiotensin II receptor blockers trans-stimulate the uptake of uric acid by human URAT1 and others inhibit the transport of uric acid ...
متن کاملUric Acid and Renal Function
Since the discovery of hyperuricemia as the cause of gout in the early 1800s, hypertension, cardiovascular disease and kidney disease have also been related to increased serum uric acid (UA) levels in subsequent years (Nakagawa et al., 2006); patients with gout had a much higher prevalence of hypertension (25-50%), mild-to-moderate kidney disease (20-60%) (Kutzing & Firestein, 2008) and cardiov...
متن کاملUric acid in advanced renal failure.
1. The results of studies of renal uric acid excretion in eleven patients with advanced chronic renal failure are presented. 2. The pyrazinamide suppression test was used to separate secretion from reabsorption of uric acid in the renal tubule. 3. There is a marked increase in the excretion and clearance of uric acid as renal function deteriorates. This was due to a striking increase in tubular...
متن کاملUric Acid-induced Phenotypic Transition of Renal
Eun-Sun Ryu, Mi Jin Kim, Hyun-Soo Shin, Yang-Hee Jang, Hack 6 Sun Choi, Inho Jo, Richard J. Johnson, and Duk-Hee Kang 7 8 9 10 The Division of Nephrology, Department of Internal Medicine,Department of 11 Molecular Medicine, Ewha Womans University School of Medicine, Ewha Medical 12 Research Center, Seoul, Korea; The Division of Renal Diseases and Hypertension, 13 University of Colorado Denver, ...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1985
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198507000-00184