Spontaneous Functional Recovery after Focal Damage in Neuronal Cultures
نویسندگان
چکیده
منابع مشابه
Gamma-hydroxybutyrate accelerates functional recovery after focal cerebral ischemia.
BACKGROUND AND PURPOSE gamma-Hydroxybutyrate (GHB), a natural metabolite of gamma-aminobutyric acid and a drug used in humans to promote slow-wave sleep and treat narcolepsy, has been suggested to protect against ischemic stroke at high doses. This study aimed to assess recovery-promoting effects of GHB at a low dose similar to that used in patients. METHODS Adult mice, subjected to 30 min of...
متن کاملOptogenetic neuronal stimulation promotes functional recovery after stroke.
Clinical and research efforts have focused on promoting functional recovery after stroke. Brain stimulation strategies are particularly promising because they allow direct manipulation of the target area's excitability. However, elucidating the cell type and mechanisms mediating recovery has been difficult because existing stimulation techniques nonspecifically target all cell types near the st...
متن کاملDifferent mechanisms of secondary neuronal damage in thalamic nuclei after focal cerebral ischemia in rats.
BACKGROUND AND PURPOSE After focal cerebral ischemia, depending on its localization and extent, secondary neuronal damage may occur that is remote from the initial lesion. In this study differences in secondary damage of the ventroposterior thalamic nucleus (VPN) and the reticular thalamic nucleus (RTN) were investigated with the use of different ischemia models. METHODS Transient middle cere...
متن کاملEarly Release of HMGB1 may Aggravate Neuronal Damage after Transient Focal Ischemia in Diabetic Rat Brain
Objective: High Mobility Group Box 1 (HMGB1) released extracellularly from necrotic cells evokes delayed inflammatory processes via interaction with the Receptor for Advanced Glycation End Products (RAGE) or Toll-like Receptors (TLR) in postischemic brain. The diabetic state (DM) aggravated cerebral ischemic injury following the stroke in rats. Therefore, we examined the behavior of HMGB1 and t...
متن کاملThe effects of early exercise on brain damage and recovery after focal cerebral infarction in rats
AIM Exercise can be used to enhance neuroplasticity and facilitate motor recovery after a stroke in rats. We investigated whether treadmill running could reduce brain damage and enhance the expression of midkine (MK) and nerve growth factor (NGF), increase angiogenesis and decrease the expression of caspase-3. METHODS Seventy-seven Wistar rats were split into three experimental groups (ischae...
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ژورنال
عنوان ژورنال: eneuro
سال: 2019
ISSN: 2373-2822
DOI: 10.1523/eneuro.0254-19.2019