Split chimerism between nucleated and red blood cells after bone marrow transplantation for haemoglobinopathies
نویسندگان
چکیده
منابع مشابه
Quantitatively different red cell/nucleated cell chimerism in patients with long-term, persistent hematopoietic mixed chimerism after bone marrow transplantation for thalassemia major or sickle cell disease.
BACKGROUND Persistent mixed chimerism represents a state in which recipient and donor cells stably co-exist after hematopoietic stem cell transplantation. However, since in most of the studies reported in literature the engraftment state was observed in the nucleated cells, in this study we determined the donor origin of the mature erythrocytes of patients with persistent mixed chimerism after ...
متن کاملPlacental/umbilical cord blood for unrelated-donor bone marrow reconstitution: relevance of nucleated red blood cells.
Placental/umbilical cord blood (PCB) is a source of hematopoietic stem cells for bone marrow reconstitution. Engraftment speed and survival are related to the total nucleated cell (TNC) dose of the graft. This study explored the possible influence on engraftment of nucleated red blood cells (NRBCs) in the graft. Automated hematology analyzers were used to enumerate TNCs. NRBCs were counted by v...
متن کاملMixed chimerism after bone marrow transplantation for thalassemia major.
Thirty-four thalassemia patients were studied for chimerism by fluorescent in situ hybridization or variable number tandem repeats after bone marrow transplantation. Mixed chimerism was detected in 9 patients with host cells ranging from 4 to 56%. One had graft rejection and the others were transfusion independent. Mixed chimerism was common but mostly without deleterious effect.
متن کاملSystematic comparison of donor chimerism in peripheral blood and bone marrow after hematopoietic stem cell transplantation
Incomplete donor chimerism (DC) after hematopoietic stem cell transplantation (HSCT) is associated with reduced overall and disease-free survival and decreasing DC can precede overt relapse of malignant diseases. Sensitive chimerism quantification may therefore allow for early therapeutic intervention, potentially improving treatment response. Frequently, post-HSCT chimerism monitoring involves...
متن کاملFlow cytometric evaluation of red blood cell chimerism after bone marrow transplantation in Iranian patients: a preliminary study.
The aim of this study was to evaluate mixed red cells population and red blood cell chimerism after hematopoietic stem cell transplantation. Red blood cell chimerism after hematopoietic stem cell transplantation was analyzed using a series of fluorescein isothiocyanate-conjugated monoclonal antibodies (BioAtlantic, France) directed against ABH, Rh (D, C, E, c, e), Kell, Duffy, Kidd, and Ss anti...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chimerism
سال: 2011
ISSN: 1938-1956,1938-1964
DOI: 10.4161/chim.15057