Spironolactone response related to plasma canrenone concentration [proceedings]
نویسندگان
چکیده
منابع مشابه
Determination of Spironolactone and Canrenone in Human Plasma by High-performance Liquid Chromatography with Mass Spectrometry Detection
A new simple, sensitive and LC-MS/MS method for quantification of spironolactone and its metabolite, canrenone, in human plasma is proposed. The analytes were analysed on a C18 column at 48 oC, by using a mobile phase of 58 % methanol, 42 % 10 mmol dm ammonim acetate in water and a flow rate of 1 mL/min. The detection of both analytes in plasma was performed as follows: ESI+, EIC (m/z 169;187;2...
متن کاملDigoxin assays: frequent, substantial, and potentially dangerous interference by spironolactone, canrenone, and other steroids.
BACKGROUND A case of digoxin toxicity resulted from falsely low values with the MEIA II assay for digoxin (AxSYM; Abbott). The low results were caused by negative interference from canrenone and spironolactone, the latter of which has recently been advocated for the treatment of severe heart failure. Analytical interference from spironolactone has been reported, but little information is availa...
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Plasma levels of canrenone and androgen receptoractive materials (ARM) were determined during long-term oral K-canrenoate or spironolactone therapy in cirrhotics with chronic recurrent ascites. Mean plasma canrenone level was approximately 3 times higher under K-canrenoate than under spironolactone treatment; moreover, the levels were not dose related. Either type of treatment did not affect pl...
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Hypertriglyceridemia is frequently observed in subjects with coronary artery disease and is particularly common in young males (1, 2). A number of factors undoubtedly contribute to the increased levels of plasma triglycerides; among these, the role of exogenous dietary fat has been established (3). The magnitude of endogenous triglyceride synthesis has not been measured in patients with hypertr...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1979
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1979.tb00971.x