Spirocyclic Amide Acetal Synthesis by [CpRu]‐Catalyzed Condensations of α‐Diazo‐β‐Ketoesters with γ‐Lactams
نویسندگان
چکیده
The synthesis of spirocyclic amide acetals (33–93 %) has been achieved through Ru(II)-catalyzed condensations N-carbamate protected pyrrolidinones with metal carbenes derived from α-diazo-β-ketoesters. Thanks to the mildness diazo decomposition conditions induced by a 1 : combination [CpRu(MeCN)3][BArF] and 1,10-phenanthroline, formation sensitive products is possible. Full characterization this carbonyl-ylide mediated process provided DFT calculations.
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ژورنال
عنوان ژورنال: Helvetica Chimica Acta
سال: 2021
ISSN: ['1522-2675', '0018-019X']
DOI: https://doi.org/10.1002/hlca.202100122