Spirobicyclic diamines 1: synthesis of proline-derived spirolactams via thermal intramolecular ester aminolysis
نویسندگان
چکیده
منابع مشابه
Cyclobutane-derived diamines: synthesis and molecular structure.
Cyclobutane diamines (i.e., cis- and trans-1,3-diaminocyclobutane, 6-amino-3-azaspiro[3.3]heptane, and 3,6-diaminospiro[3.3]heptane) are considered as promising sterically constrained diamine building blocks for drug discovery. An approach to the syntheses of their Boc-monoprotected derivatives has been developed aimed at the preparation of multigram amounts of the compounds. These novel synthe...
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ژورنال
عنوان ژورنال: Tetrahedron Letters
سال: 2006
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2006.03.021