SPIRO-PYRIMIDINES. II. CYCLOHEXANE-1,5-SPIRO-PYRIMIDINES.

Antibacterial properties of 3 H-spiro[1-benzofuran-2,1'-cyclohexane] derivatives from Heliotropium filifolium.

A re-examination of cuticular components of Heliotropium filifolium allowed the isolation of four new compounds: 3'-hydroxy-2',2',6'-trimethyl-3H-spiro[1-benzo-furan-2,1'-cyclohexane]-5-carboxylic acid(2), methyl 3'-acetyloxy-2',2',6'-trimethyl-3H-spiro[1-benzofuran-2,1'-cyclohexane]-5-carboxylate (3), methyl 3'-isopentanoyloxy-2',2',6'-trimethyl-3H-spiro[1-benzofuran-2,1'-cyclohexane]-5-carbox...

Studies on Fluorinated Pyrimidines

We have previously reported on the tumor inhibitory properties of 5-fluorouracil and 5-fluoroorotic acid (3, 4), prepared by Duschinsky et al. (5), and on the initial clinical trials of 5fluorouracil with patients with far advanced solid tumors (6). The metabolism of 5-fluorouracil and 5-fluororotic acid has been studied, data on excretion and tissue distribution in mice and man have been repor...

Dum Spiro, Spero

It is my sad editorial duty to acknowledge that Professor David Hadden, previous editor of this Journal died earlier this year. As a previous editor he has his obituary published here and I thank Professor Patrick Bell for rising to this sad task so diligently. David bore his final illness with great dignity, clearly determined that while he was alive, he would live (dum vivimus, vivamus). The ...

Spiro Table of Contents

Spiro Table of Contents